Material Safety Data Sheet: Bromoacetyl Bromide
Identification
Product Name: Bromoacetyl Bromide
CAS Number: 598-21-0
Synonyms: Bromoacetyl Bromide, Acetyl Bromide, Bromo-
Recommended Use: Laboratory chemical, synthesis intermediate
Manufacturer: Chemical supplier address and contact info
Emergency Contact: Poison control, local emergency service phone
Hazard Identification
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation), Corrosive to skin and eyes, Respiratory irritant
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage. Fatal if inhaled. Harmful if swallowed or in contact with skin. May cause respiratory irritation.
Precautionary Statements: Avoid all contact. Use only outdoors or in well-ventilated areas. Wear chemical-resistant gloves, protective clothing, face shield and eye protection.
Pictograms: Skull and crossbones, Corrosion, Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin and eyes
Composition / Information on Ingredients
Chemical Name: Bromoacetyl Bromide
Concentration: 99% or higher
CAS Number: 598-21-0
Impurities: Includes trace stabilizers or water, exact components depending on supplier
First Aid Measures
General Guidance: Remove victim from contaminated area immediately. Provide fresh air.
Inhalation: Move to fresh air. Get medical help immediately. If not breathing, give artificial respiration.
Skin Contact: Take off contaminated clothes. Rinse skin with large amounts of water for 20 minutes. Get medical help.
Eye Contact: Rinse eyes with water for at least 15 minutes, holding eyelids open. Remove contact lenses if present. Immediate medical care is needed.
Ingestion: Rinse mouth with water but no induced vomiting. Immediate medical care. Never give anything by mouth if person is unconscious.
Medical Attention: In all cases, immediate medical intervention is critical due to corrosive and systemic toxicity.
Fire-Fighting Measures
Suitable Extinguishing Media: Use dry chemical, CO₂, or foam. Do not use water directly on the chemical.
Hazards from Combustion: Releases toxic gases, including hydrogen bromide, carbon monoxide, carbon dioxide, acidic fumes
Protective Equipment: Full body, self-contained breathing apparatus, and protective gear for firefighters
Additional Notes: Approach from upwind and keep containers cool with water spray, avoiding direct water contact with the material
Accidental Release Measures
Personal Precautions: Evacuate area. Wear full protective gear, including self-contained breathing apparatus.
Environmental Precautions: Prevent entry into waterways, drains, soil. Alert environmental protection authorities.
Spill Cleanup: Absorb liquid with inert material such as dry sand or earth. Avoid using combustible material. Collect and dispose following hazardous waste procedures. Wash area thoroughly with water after removal but avoid splashing.
Ventilation: Ensure adequate ventilation in the affected area
Handling and Storage
Handling: Only experienced personnel wearing proper protective gear should handle. Use in a fume hood. Prevent contact with skin, eyes, and clothing.
Hygiene Measures: Shower and change clothing after work. No eating, drinking, or smoking in work area.
Storage: Store in tightly closed containers at cool, dry, well-ventilated locations away from moisture, bases, acids, oxidizers, or food and feed. Avoid temperature extremes and direct sunlight.
Storage Incompatibility: Do not store alongside strong bases, amines, water, oxidizers
Exposure Controls and Personal Protection
Exposure Limits: No established OSHA/NIOSH limits, but minimize all exposure
Engineering Controls: Chemical fume hood, eye wash stations, safety showers
Respiratory Protection: Approved respirator for organic vapors and acid gases whenever airborne exposure is possible
Skin Protection: Chemical-resistant gloves, full lab coat, chemical apron
Eye Protection: Face shield and tight goggles
Other Protection: Cover all exposed skin. Remove contaminated clothes and wash before reuse
Physical and Chemical Properties
Appearance: Colorless to pale yellow liquid
Odor: Pungent, irritating
Odor Threshold: Data not available
pH: Not applicable (reacts with water)
Melting Point: -56°C
Boiling Point: 102°C
Flash Point: Not established, combustible
Evaporation Rate: No data
Flammability: Flammable vapors
Vapor Pressure: 7 mmHg at 20°C
Vapor Density: Heavier than air
Relative Density: 2.54 g/cm³
Solubility: Decomposes in water
Partition Coefficient: No data
Auto-ignition Temp: No data
Decomposition Temp: No data
Viscosity: Data not available
Stability and Reactivity
Chemical Stability: Unstable in presence of moisture and light, hydrolyzes rapidly
Possible Reactions: Violent exothermic reaction with water, alcohols, amines, bases
Hazardous Decomposition Products: Hydrogen bromide, bromine, carbon monoxide, carbon dioxide
Conditions to Avoid: Exposure to moisture, heat, sunlight, incompatible materials
Polymerization: Not reported, but decomposition possible under improper storage
Toxicological Information
Routes of Entry: Inhalation, dermal, ingested, ocular
Acute Effects: Severe chemical burns, pulmonary edema, systemic toxicity, may be fatal
Chronic Effects: Risk of delayed lung injury, chronic inflammation, dermatitis
Toxicity Data: Oral LD50 (rat): 290 mg/kg. Inhalation LC50 (rat): low concentration, limited data. Skin irritation studies indicate corrosive action
Symptoms: Cough, shortness of breath, burns, possible delayed pulmonary oedema
Cancer, Mutagenicity, Reproductive Effects: Not classified as carcinogenic; not expected to cause genetic or reproductive toxicity, but no full studies available
Ecological Information
Environmental Fate: Reacts with water, forming toxic products. Does not persist in environment due to reactivity.
Aquatic Toxicity: Harmful to aquatic organisms due to acidity and toxic byproducts.
Soil Mobility: Binds quickly with water and organic matter, short persistence.
Bioaccumulation: Not expected in standard conditions.
Degradation: Rapid in moist/unprotected environment, hydrolysis yields bromoacetic acid and hydrobromic acid
Disposal Considerations
Waste Treatment Methods: Do not pour into drains or environment. Keep material in clearly labeled hazardous waste container.
Neutralization: Trained personnel may neutralize under controlled conditions using sodium bicarbonate solution.
Disposal Recommendations: Incinerate at approved facility. Follow local, regional, and national hazardous waste regulations. Seek guidance from regulatory agency and hazardous waste specialist.
Contaminated Packaging: Triple rinse and dispose as hazardous material
Transport Information
UN Number: UN 2514
UN Proper Shipping Name: Bromoacetyl Bromide
Transport Class: 6.1 (Toxic substances)
Packing Group: I (high danger)
Hazard Labels: Toxic, Corrosive
Marine Pollutant: Yes
Special Transport Precautions: Keep in appropriate leak-proof, sealed containers; segregate from incompatible substances during travel; carrier must have spill protocol and personal protection ready
Regulatory Information
OSHA: Classified as highly hazardous; follow workplace chemical standards
TSCA: Listed
SARA Title III: Section 313 – reportable chemical
REACH: Regulatory compliance may be required
WHMIS (Canada): Class E (Corrosive), D1A (Very toxic material)
Other Regulations: Subject to control for possession, storage, environmental release; see specific local laws for additional restrictions or reporting
