MSDS for 2-Bromo-2-Methylpropionic Acid

Identification

Product Name: 2-Bromo-2-Methylpropionic Acid
Synonyms: α-Bromo-α,α-dimethylacetic acid; 2-Bromo-2-methylpropanoic acid
CAS Number: 598-31-2
EC Number: 209-940-0
Recommended Use: Chemical intermediate in organic synthesis, research reagent
Supplier: Contact details for supplier, including address, phone, and emergency telephone number
Emergency Contact: CHEMTREC or national poison center information

Hazard Identification

GHS Classification: Acute Toxicity (Oral), Skin Corrosion/Irritation, Serious Eye Damage/Irritation
Label Elements: Signal Word: Danger
Hazard Statements: Harmful if swallowed. Causes severe skin burns and eye damage.
Precautionary Statements: Do not breathe dust or vapor. Wash thoroughly after handling. Wear protective gloves, clothing, and eye/face protection. If swallowed, rinse mouth and call a poison center. If on skin, wash with water. If in eyes, rinse with water for several minutes.
Physical Hazards: Corrosive
Health Hazards: May cause burns to mucous membranes, eyes, and skin. Inhalation may cause respiratory tract irritation and burns.

Composition / Information on Ingredients

Chemical Name: 2-Bromo-2-Methylpropionic Acid
Concentration: ≥99% (as supplied)
Molecular Formula: C4H7BrO2
Molecular Weight: 167.00 g/mol
Impurities: May contain trace amounts of related brominated acids (typically less than 0.5%)
Additives: None reported or intentionally added

First Aid Measures

Inhalation: Move exposed person to fresh air. If breathing has stopped, begin artificial respiration. Obtain medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing; wash exposed area with soap and water for at least 15 minutes. Immediate medical attention recommended.
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Seek urgent medical help.
Ingestion: Rinse mouth; do not induce vomiting. Never give anything by mouth to an unconscious person. Urgent medical attention needed.
Important Symptoms/Effects: Burning sensation, coughing, shortness of breath, redness, missed skin patches, severe eye irritation and possible blindness.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards Arising from the Chemical: Releases toxic fumes of hydrogen bromide, carbon oxides under fire conditions
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Evacuate area, prevent runoff into drains, use water spray to cool unopened containers
Flash Point: Data not readily available (use standard precautions for combustibles)

Accidental Release Measures

Personal Precautions: Avoid contact with spilled product, ensure adequate ventilation, use personal protective equipment including gloves, goggles, and laboratory coat or apron
Environmental Precautions: Prevent entry into soil, sewers, surface or groundwater; notify authorities if large spills occur
Methods for Clean-Up: Absorb with appropriate inert material (sand, earth, vermiculite), collect in a tightly closed container for proper disposal
Decontamination: Wash area with plenty of water and detergent to remove residues
Other: Evacuate unnecessary personnel from spill site, avoid raising dusts or aerosols

Handling and Storage

Safe Handling: Avoid skin, eye, and clothing contact. Use only in a chemical fume hood or well-ventilated area. Do not breathe vapors or dust. No eating, drinking, or smoking in work area. Wash hands thoroughly after use.
Safe Storage: Store in a tightly closed container, in a cool, dry, well-ventilated area, protected from moisture and direct sunlight. Segregate from bases, oxidizing agents, and reducing agents.
Incompatible Materials: Strong bases, oxidizers, reducing agents, strong acids
Specific Storage Requirements: Use shatterproof containers, store at temperatures below room temperature if possible, separate from food and feedstuffs, label shelves clearly

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established
Engineering Controls: Chemical fume hood, eyewash stations, safety showers
Personal Protective Equipment: Nitrile or butyl rubber gloves, chemical safety goggles, lab coat or coveralls, appropriate respiratory protection if dust or vapor may be generated
Hygiene Measures: Remove and wash contaminated clothing before reuse; ensure good industrial hygiene practices are in place
Environmental Controls: Prevent release to environment by using containment

Physical and Chemical Properties

Appearance: White to pale yellow crystalline solid
Odor: Slight, sharp, irritating odor
Odor Threshold: Not available
pH: Acidic in aqueous solution
Melting Point/Freezing Point: 49-55°C
Boiling Point: Decomposes before boiling
Flash Point: Not established; caution advised as combustible
Evaporation Rate: Not determined
Flammability: Not readily flammable
Upper/Lower Explosion Limits: Not available
Vapor Pressure: Very low at 20°C
Vapor Density: Heavier than air (relative density not established)
Relative Density (Water=1): 1.49
Solubility: Soluble in water, ethanol, slightly soluble in ether
Partition Coefficient (Log Kow): Not determined
Auto-ignition Temperature: Not available
Decomposition Temperature: >150°C (decomposes with toxic fumes)

Stability and Reactivity

Chemical Stability: Stable in sealed, moisture-free containers under recommended conditions
Hazardous Reactions: Reacts with strong bases, strong oxidizing agents, and reducing agents
Conditions to Avoid: Exposure to moisture, elevated temperatures, incompatible substances
Incompatible Materials: Strong bases, oxidizing materials, strong reducing agents
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide, other irritating fumes

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat) >300 mg/kg (estimated, not definitive)
Corrosive Effects: Causes burns to skin, eyes, mucous membranes
Carcinogenicity: Not classified as a human carcinogen by IARC, NTP or OSHA
Mutagenicity: No data available
Reproductive Toxicity: No specific data
Other Effects: Severe respiratory tract, gastrointestinal tract, and skin irritation or burns
Target Organs: Respiratory system, eyes, skin, gastrointestinal tract

Ecological Information

Aquatic Toxicity: Harmful to aquatic life with long lasting effects (data based on structure–activity relationships and experience with similar compounds)
Persistence and Degradability: Not rapidly biodegradable, may persist in the environment
Bioaccumulative Potential: Not expected due to low octanol–water partition coefficient
Mobility in Soil: Moderate due to water solubility, may leach to groundwater
Other Adverse Effects: Releases hydrogen bromide on degradation which acidifies aquatic environments

Disposal Considerations

Waste Treatment Methods: Collect and contain for disposal by a licensed chemical waste contractor
Disposal of Product: Incinerate in a chemical incinerator equipped with afterburner and scrubber; avoid release to environment
Disposal of Contaminated Packaging: Triple rinse containers before disposal; puncture and dispose in accordance with all local, regional, national, and international regulations
Precautions: Do not allow residues to enter water systems or soil, do not mix with ordinary trash

Transport Information

UN Number: UN3261
Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (contains 2-Bromo-2-Methylpropionic Acid)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Environmental Hazard: Harmful to aquatic environment (mark as marine pollutant if by sea)
Special Precautions: Avoid contact with incompatible materials, use dedicated containers, label all packaging clearly, transport with proper documentation
Transportation Regulation References: Compliant with DOT, IATA, IMDG codes for hazardous chemicals

Regulatory Information

OSHA Status: Considered hazardous under OSHA regulations
TSCA Status: Listed on the US TSCA inventory
SARA Title III: Not listed under extremely hazardous substances but reportable for significant accidental releases
Canada (DSL/NDSL): Listed on Domestic Substances List
REACH (EU): Pre-registered or subject to restrictions depending on use
Other Regulatory Listings: Follow state, national, and international guidelines for hazardous chemicals
Additional Information: Follow workplace right-to-know requirements, ensure all staff are trained regarding hazards and first aid